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Furthermore, most studies lack integrated multi-omics approachescomprehensive analyses combining microbiome profiles (microbial community structure), metabolome data (SCFA concentrations), and host transcriptome or epigenome alterationsthus limiting construction of a holistic mechanistic framework (164)
PI/Ca : Experimental studies have shown that increased cAMP and PKA activation inhibits methacholine- and histamine-induced phosphoinositide (PI) hydrolysis and its effect to cause Ca2+ mobilization (Hoiting et al, 1996
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