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Limited safety data on combinations in existing literature further emphasizes the need for cautious protocol design

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The interplay among multiple pathobiological pathways, such as the persistence of viral reservoirs, direct SARS-CoV-2-related tissue damage, dysbiosis, ongoing inflammation, autoimmunity and microthrombi phenomena, has been proposed as the main driver of Long COVID [9, 10]

However, it should be noted that while MoCA can robustly detect mild cognitive impairment, detection of subtle cognitive impairments requires analyses of its sub-scores (Charest et al., 2020), which were not conducted by the above-mentioned studies