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Kerendia (finerenone) granted expanded indication in the EU for broad range of patients with chronic kidney disease and type 2 diabetes

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Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

Weathered microplastics in human blood: unraveling the effect of structural changes at the particle surface on coagulation and platelet activation

Response: We appreciate commenters' feedback regarding the characterization of preparation services, such as cell collection by apheresis and local processing, for CAR T-cell therapies

What It Is Class: Multi-compound metabolic research blend Primary pathways: NAD + -linked cellular energy systems, mitochondrial stress signaling, and NNMT-associated metabolic biochemistry Research focus: Mitochondrial function, energy balance, metabolic resilience, and adiposity-related endpoints in preclinical models Proposed Mechanisms (Preclinical) NAD + & Cellular Energy Support NAD is a core coenzyme involved in redox reactions, mitochondrial respiration, and energy-transfer pathways in cells