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In addition, it is clear that the gut microbiota, involved in the energy metabolism of host proteins and peptides, will produce various bioactive compounds, including tryptophan, SCFAs, branched-chain fatty acids, ammonia, phenols, indoles, and amines (Ratzke and Gore, 2018)

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These findings position tirzepatide as potentially one of the most effective MASH therapies ever studied

Rapid weight reduction induced by GLP-1RAs can improve body satisfaction and quality of life, but it may also create unrealistic expectations or dependence on medication for weight control (64)

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The change effectively restricted pharmacies from compounding them