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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

Evidence levels range from FDA-approved (for narrow indications) to purely preclinical

The FDA's announcement comes months after drugmaker Novo Nordisk told the agency that all dosages of its semaglutide product had become fully available nationwide

We will update this article as new research is published so it can serve as a resource to clinicians and policymakers

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Animals 8(11):189 Xu FM, Hou SW, Wang GX, Gong JY, Zhou L, Gao S (2021) Effects of zymolytic black soldier fly ( Hermetia illucens ) pulp as dietary supplementation in largemouth bass ( Micropterus salmoides )