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In recent years, the scientific community has focused on two key endogenous molecules NAD (Nicotinamide Adenine Dinucleotide) and reduced glutathione (GSH) whose progressive depletion with age is now correlated with the main signs of cutaneous and systemic ageing. NAD: the anti-ageing metabolic powerhouse NAD is an essential coenzyme involved in hundreds of redox reactions and a fundamental substrate for sirtuins and PARPs, pro-longevity enzymes that regulate DNA repair and mitochondrial function

Any temperature excursion above 25C for more than 4 hours causes irreversible protein denaturation

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties

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A 1453 , 3442 (2016)

Disruption of this inhibitory interaction allows increased nitric oxide production, which is relevant to endothelial signaling and vascular responsiveness in experimental systems [3]