Clinical Efficacy: The SURMOUNT-5 Numbers in Plain English In SURMOUNT-5, 32% of tirzepatide patients lost at least 25% of their body weight
This confirmed that the dual agonist mechanism provides meaningful advantages over single GLP-1 agonism alone
And while NAD+ is generally safe alongside most medications and supplements, its smart to double-check with your provider if youre taking anything new especially stimulants or anything that affects your nervous system
The answer is yes, but there are a few things to keep in mind
On the other hand, ongoing tiredness, especially if it worsens over weeks, may mean you are not eating or drinking enough, or that you have a side effect that needs to be checked
Beyond appetite control, GLP-1 medications also improve insulin sensitivity and reduce blood sugar spikes, which play an important role in fat storage