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Reported concerns include local injection reactions, potential immunogenicity from copper exposure with chronic use, and theoretical risks if peptides activate unintended growth pathways

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doi: 10.1089/jir.2011.0065 233 McKinneyEFSmithKG

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In the intrinsic pathway, oxidative stress or GSH depletion induces BAX SSG at Cys62, promoting its mitochondrial translocation and subsequent activation of CASP9 and CASP3 44

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