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M., Payette, H., & Wagner, J

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In this combination, dasatinib and quercetin effectively reduced the number of senescent cells in adipose tissue and the vasculature, while fisetin modulated the inflammatory SASP, improving overall tissue function and reducing the risk of age-related diseases such as cardiovascular disease and osteoporosis

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Hepatic function plays a minimal role in GLP-1 elimination, as these medications are primarily degraded by proteolytic enzymes throughout the body rather than hepatic metabolism