The active ingredient in the incretin mimetic is dulaglutide, which shares 90% of the amino acid sequence with naturally occurring GLP-1
Blood was collected into tubes containing 1.25 mg EDTA and aprotinin (500 kallikrein-inhibiting units/ml blood) (Wako Pure Chemical Industries), and all samples were centrifuged within 2 h of collection
CPi: Conceptualization, Resources, Writing review & editing
In conclusion, the specific mechanism by which GLP-1RAs act on EAT remains elusive
The clinical importance of GLP-1 has been highlighted by the development of GLP-1 receptor agonists (such as semaglutide and liraglutide) for managing type 2 diabetes and, under specific NICE criteria, for weight management
Its clinical application is no longer confined to hypoglycemic reduction, and the types of GLP-1RA used in clinical applications are also increasingly more diverse