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53 Pancreatic and Hepatobiliary Events Pancreatitis and Pancreatic Disorders It has been suggested that GLP-1 RAs may influence pancreatic physiology through multiple mechanisms, including effects related to rapid weight loss and gallstone formation, which have been hypothesized to contribute indirectly to pancreatitis risk

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Additionally, this combinatorial therapy significantly ameliorated cognitive function [377]

doi: 10.1016/j.atherosclerosis.2008.10.016 13

6,18,19 Similar to sitagliptin, saxagliptin is excreted by the kidneys, but it also undergoes hepatic metabolism