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[57] Several serious, even life-threatening diseases cause elevated serum haptocorrin, measured as abnormally high serum vitamin B 12 , while at the same time potentially manifesting as a symptomatic vitamin deficiency because of insufficient vitamin bound to transcobalamin II which transfers the vitamin to cells

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Briefly, the pathogenesis of type 1 diabetes results from a triad of failures is a permissive genetic background in immunoregulation, a disruption of central and peripheral tolerance mechanisms, and an environmental insult that ignites and propagates a targeted immune attack on insulin-producing pancreatic beta cells