Contribution of dietary intakes of antioxidants to homocysteine-induced low density lipoprotein (LDL) oxidation in atherosclerotic patients
In the SURMOUNT-5 trial, published in the New England Journal of Medicine, patients receiving tirzepatide had a mean percent decrease in body weight of 20.2%, compared with 13.7% for those receiving semaglutide,over 72 weeks
Rothman KJ, Greenland S, Lash T (2008) Modern epidemiology
Along with a possible reduction of the antiplatelet effects of NO, this increase in thromboxane biosynthesis might contribute to platelet activation in moderate hyperhomocysteinemia (Durand et al, 1997a)
Weight loss proved to be the most common concern, preventing the trial completion of 1 patient, and proved fully reversible on cessation of the drug in the open trial
doi: 10.1155/2022/5558599 303 ZhouYYHeCHLanHDongZWWuYQSongJL