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In fasted healthy normal weight patients, GLP-1 (7-36) amide injection reduced fMRI activity induced by food images, in all brain areas studied (amygdala, insula, caudate, NAc, orbitofrontal cortex, and putamen), compared to saline injection [43]

These trials are of low quality, and as such, use in widespread clinical practice is premature

Acute pancreatitis likely due to semaglutide

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Weight loss drugs and diabetes drugs are increasingly popular and some of the drugs potentially linked to these serious health problems are household names. GLP-1 drugs involved in recent claims include: Ozempic Wegovy Mounjaro Saxenda Trulicity Rybelsus Ozempic, Wegovy, and Rybelsus are brand names of semaglutide

Valproic acid (VPA) is a broad-spectrum anti-epileptic drug [133]