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GLP-1 medications work by quieting hunger signals in your brain and slowing digestion, which is exactly why so many patients lose weight

As the figure shows, both GLP-1RAs and SGLT-2is could reduce the MACE, with the SGLT-2is treatment seem to be nominally associated with lower risk of heart failure and total mortality, whereas with GLP-1RAs seem to be associated with lower risks of stroke and peripheral artery disease

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Its robust evidence

This significantly improves bioavailability, sometimes reaching up to 80%, which is comparable to the efficacy of low-dose injections, without the needle

Moreover, retatrutide reduced time of relaxation (Fig