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Finally, to address potential pleiotropic effects, we excluded SNPs associated with other potential confounders identified through PhenoScanner ( Outcome sources To minimize potential bias due to population diversity, we restricted our drug target MR analysis to participants of European ancestry

The subsequent discovery of glucagon-like immunoreactivity in the gut led to the realization that proglucagon is synthesized in enteroendocrine cells intercalated between enterocytes and distributed throughout the intestine

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These are not recommendations for clinical use but rather data points from published studies and clinical protocols