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Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1

A key event in this activation is the unwinding of the U4/U6 snRNA duplex, followed by the release of the U4 snRNP and B-specific proteins, and the recruitment of various protein complexes such as the NTC (Nineteen), NTR (Nineteen-related), RES (retention and splicing), and IBC (intron-binding) 12,13,14,15,16

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Newman AC, Maddocks OD

NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRIs Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI

(2021) 9:e11894)