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Database searches for cagrilintide and retatrutide trials

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Limited activity tolerance, from walking long distances to exercising

Because it hasn't gone through the rigorous testing required for medical use, its safety for humans is largely unknown

The published preclinical literature uses weight-adjusted rodent dosing that doesn't translate cleanly to fixed human protocols, so researchers extrapolate

It activates the Wnt/beta-catenin signaling pathway, which promotes the anagen (active growth) phase and extends its duration while shortening the telogen (resting) phase