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Ex-4 is capable of suppressing the production of reactive oxygen species (ROS) in various cell types, with ROS playing a critical role in promoting the formation of tumor-associated neutrophil extracellular traps (NETs)

Therefore, the combination of SGLT2 inhibitors and GLP-1 receptor agonists provides an effective approach for modifying the development of a medical condition and enhancing patient outcomes in high-risk groups [60,61]

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Recent research emphasizes the role of hormones that communicate with the hypothalamus through the gut-brain axis, affecting appetite, insulin secretion, and body weight via specific signaling pathways

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