(5.9) Adverse Reactions/Side Effects The most common adverse reactions reported in 5% of patients simultaneously started on sitagliptin and metformin and more commonly than in patients treated with placebo were diarrhea, upper respiratory tract infection, and headache
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In this context, the glucagon-like peptide-1 (GLP-1) receptor system has emerged as a paradigm-shifting model ( 3 GLP-1 receptor signaling and GLP-1RA in metabolic disorders The global prevalence of metabolic dysfunction, encompassing obesity and T2DM, has reached pandemic proportions (Rohm et al., 2022), and organelle dysfunction (Lemmer et al., 2021)
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