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When there is a change in DOF in allosteric site, rigidity-based allostery algorithm mathematically certifies and quantifies the corresponding change in DOF in the active site
doi: 10.1111/j.1365-4362.1992.tb02688.x
Chen HM, DeLong CJ, Bame M, Rajapakse I, Herron TJ, McInnis MG, et al
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