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glycine via thermoregulation and sleep onset)

Commonly, individuals may notice swelling, redness, or irritation at the injection site, which are mild and typically subside within a few hours

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However, despite these advancements, a significant challenge that persists is the subset of patients who are resistant to or have limited response to immunotherapy (170), particularly in patients with low tumor mutational burden and immunogenic neoantigens (171, 172)