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The rapid production of ROS in activated neutrophils, which requires increased pentose cycling, and thus increased G6PD activity, acts to promote NETosis via oxidative inhibition of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) ( Overall, the uniquely rapid need for neutrophil effector functions, such as NETosis, phagocytosis and degranulation, to be mobilized quickly in the innate immune response necessitates brisk production of NADPH, which is chiefly controlled by the PPP rate-limiting activity of G6PD

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Other reviews have been published on the origins and enzymatic differences between the two classes of TrxRs, and the reader is referred to these for such details [48, 52, 54, 62]

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Riboflavin, Vitamin B6 & B12 contribute to normal energy-yielding metabolism