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Starvation, as induced by caloric restriction, downregulates mTOR activity and activates autophagy (307, 308)

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Verteporfin (VP), a small-molecule inhibitor that suppresses fibrosis-related gene expression induced by mechanical stimuli, selectively interferes with YAP, a key regulator of mechanical signaling, forming complexes with TEAD transcription factors in the nucleus

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Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism