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Patients should be counseled ahead of time that transient worsening of diabetic retinopathy or macular edema can happen whenever there is rapid glucose improvement, but that there are significant long-term benefits for diabetic retinopathy

G.StathopoulosC.DAlessandroA.et al (2024b)

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Tell surgeons and anesthesiologists youre on semaglutide

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Using SH-SY5Y cells exposed to high glucose concentrations to induce hyperglycemia, disruptions in glucose sensing leads to activation of the phosphorylated protein kinase B (pAkt)/GSK-3 signaling pathway, and increased expression of BACE and A42, an effect that can be reversed via pretreatment with melatonin [62]