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In rodents, -cell replication increased by 2.8-fold after partial pancreatectomy [4] and by 2.5-fold during pregnancy [5]

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High doses of oral folate and sublingual vitamin B12 in dialysis patients with hyperhomocysteinemia

Renal function should be monitored in patients with pre-existing chronic kidney disease, particularly during dose escalation when nausea and vomiting can cause dehydration [3]