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Potential interventions and therapeutic strategies Given the central role of oxidative stress, inflammation, endothelial dysfunction, and coagulation disturbances in MNP-induced cardiotoxicity, several therapeutic strategies have emerged based on experimental evidence: Antioxidant therapy (NAC, Resveratrol, Apocynin, CoQ10) N-acetylcysteine (NAC) is shown to significantly attenuate ROS production and restore NO bioavailability and eNOS activity in endothelial models and in vivo assaysindicating its potential to counteract MNP-induced redox imbalance [147]

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