In each case, difference electron density maps contoured at 3 show each inhibitor covalently bound to the S atom of C32 in GSTO1 (Supplementary Fig
It has also been shown that enzyme induction of phase II enzymes can lead to hepatomegaly without hepatocellular hypertrophy (Makino et al
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As we discussed above, glutathione reduced ethyl ester is definitely the form youll want to use for cell culture as it has a much higher cellular uptake (Levy et al, 1993)
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