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King TEJ, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA, Jr., et al

Male Sprague-Dawley rats (Taconic derived) weighing 390-450 g were maintained with free access to water and food (Harland Tekland F6 rodent diet, Madison, WI) except the night prior to surgery when food was removed

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Gigascience 6(6):033

The permeability of the small hydrophilic marker dye fluorescein was at the level of non-treated control (4.75 10 6 cm/s) in all groups at basal conditions which was significantly increased by 40% after cytokine treatment (Fig

These results indicate that APR-246 induces p53-independent effects in these cells and that these off-target effects prevent us from detecting any mutant-specific effects even at low doses