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Some of these polymorphic variants include Arg142His, Arg151Cys, Arg160Trp, and Asp294His substitutions which are associated with the red hair/fair skin phenotype and enhanced risk of developing melanoma [41, 42]

Diabetes is a metabolic disorder marked by relative or absolute insulin secretion deficits leading to chronic hyperglycemia and carbohydrate, lipid, and protein metabolism abnormalities