Erythromycin antagonises the deceleration of gastric emptying by glucagon-like peptide 1 (GLP-1) and unmasks its insulinotropic effect in healthy subjects
This appetite suppression contributes to weight loss, which varies by dose and individual factorsclinical trials have shown weight reductions typically ranging from 5-15% in people with type 2 diabetes and higher (up to 20% at maximum doses) in people without diabetes over 72 weeks
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Thirteen states cover GLP-1s for obesity treatment under Medicaid, according to a January 2026 report from KFF, a nonpartisan research organization focused on health policy
Additionally, it helps lower the chances of serious heart-related issues like heart attacks, strokes and cardiovascular death in adults who already have heart disease and are either obese or overweight
Instead, it is a popular phrase that originated with Ozempic use but is now commonly used when people refer to oral side effects associated with all GLP-1 medications
