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The Tarar et al

Preclinical models indicate that the GLP-1 R system has evolved, at least in part, to regulate feeding-related motivation ( Repeated dosing is probably crucial for positive effects in depression and suicidality

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LlewellynSmith et al., 2011) and thus might be a target for central GLP1 under physiological conditions as well as for truly supraphysiological amounts of circulating GLP1 and GLP1 receptor agonists

Originally developed for type 2 diabetes, these prescription medications are now also approved for chronic weight management in certain individuals

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