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Low levels have been linked to several issues, including a decline in brain function and a possible link to depression

You should seek medical advice if urine is persistently red, brown, very dark, or foamy, or if you notice pain, burning, or swelling

PMC4217450

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Less severe types of GI bleeding, such as hemorrhoids, may stop independently

Sometimes, these cells cluster together instead of distributing evenly, creating the concentrated pigmentation we see as a birthmark mole