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doi: 10.1002/hep.28736

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9 During pathological states, reaction between nitric oxide and superoxide can generate highly reactive peroxynitrite (ONOO-) radicals, which are implicated in lipid peroxidation

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Moreover, MMPs release growth factors from carrier proteins, inactivate proteinase inhibitors, and influence inflammatory cytokines and chemokines that can also be responsible for joint destruction [8]