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Results after 8 weeks: Body weight: 3.0% Waist circumference: 1.8% Testosterone: 46.2% Estrogen: 21.2% What Do These Findings Mean

These include digestive adjustments such as bloating, gas, or changes in bowel habits during the first few days

Oral orforglipron is available in the US and could soon be rolled out in the UK

Diabetes Care 2021;44:290-6.ArticlePubMed 94

Human / Clinical Evidence: What We Know Now we move from what could happen, to what seems to happen in people

Abbreviations AMLN : Amylin liver nonalcoholic steatohepatitis ER : Endoplasmic reticulum FFA : free fatty acids FFD : Fast-food diet GAN : Gubra amylin GLP-1RAs : Glucagon-like peptide-1 receptor agonists HFCC : High-fat high-cholesterol high-cholic acid HFCC-CDX : High-fat high-cholesterol high-cholic acid diet with hydroxypropyl--cyclodextrin in drinking water HFD : High-fat diet HTFD : High-trans-fat high-fructose high-cholesterol diet MCD : Methionine-choline deficient NAFLD : Nonalcoholic fatty liver disease NLRP3 : Nod-like receptor protein amilypyrin domain containing 3 ROS : Reactive oxygen species SD : Sprague-Dawley TNF- : Tumor necrosis factor- References Henry L, Paik J, Younossi ZM (2022) Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world