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Results showed that ASX significantly reduced clinical skin severity scores and reduced spontaneous scratching in AD mice

Topical Glutathione (Limited Effectiveness) Creams, serums, and lotions containing glutathione exist, but the molecule is relatively large and does not penetrate the skin barrier efficiently

Pirfenidone, an approved IPF antifibrotic, indirectly inhibits TGF1mediated epithelial-mesenchymal transitions by suppressing MUC1CT phosphorylation and catenin signaling, reducing SMA and collagen expression in preclinical models (166)

As a monotherapy, baicalein demonstrated superior survival benefit in mice following TBI compared to Fer-1 or Lip-1

Meta-analytical evidence has demonstrated limited benefit over placebo in reducing OA pain, particularly in knee and hip OA, and its use is increasingly de-emphasized in clinical guidelines ( TABLE 2 Pharmacological therapies for osteoarthritis: clinical use, evidence, and limitations