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Nutrients 9 (11), 1211

Metformin also works well as a foundation medication when combined with GLP-1 therapy

SPD can cause serious disruptions in ones personal life

However, safety concerns have persisted for years regarding the pancreatic effects of GLP-1 RAs

Together, slower digestion and a stronger fullness signal sharply reduce the drive to eat, and the weight comes off commonly around 15 percent of body weight with semaglutide and up to roughly 20 percent with tirzepatide in head-to-head clinical trials, though real-world results are often more modest

As with other GLP-1 agonists, prescribers adding dulaglutide to a patient's regimen may need to reduce the dose of concomitant sulfonylurea or insulin, to reduce the risk of hypoglycaemia