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For each biomarker gene, a signature score was computed to evaluate whether the gene was differentially expressed between cases and controls across various studies included in the meta-analysis

It affects nerve cells in the brain and spinal cord

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47 In addition to its direct effects on gallbladder contraction and sphincter of Oddi relaxation, CCK is involved in molecular and neuronal pathways that regulate both gallbladder function and satiety

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The open question for botanical supplement ingredients like berberine is whether they meet the same criteria in a consumer patch format