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Temperature excursions above 8C accelerate this timeline even brief exposure to room temperature (25C) for 24 hours reduces stability to 14 days or less

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For many people, nausea tends to be dose-dependent it is often worse when starting treatment or after a dose increase, and it may improve over several weeks as the body adjusts

Some researchers have studied vitamin B12 to find out if it can increase energy and endurance during exercise, but the results are inconclusive