Free Rad Biol Med 40:92839 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA (2004) JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinsons disease
Glutathione is generally well-tolerated but can cause mild gastrointestinal side effects and, possibly, skin flushing
The same results were observed in a small study in older humans who had high oxidative stress and glutathione deficiency inside cells
doi: [Elsevier] Ajith TA, Ranimenon
Koo JY, Lowe NJ, Lew-Kaya DA, Vasilopoulos AI, Lue JC, Sefton J, Gibson JR
However, at early stages of disease development, hepatic metabolites and other compensatory mechanisms may prevent histologic inflammation