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However, there are some theories: Metabolism slows down Feeling tired or lacking in energy leads to a lower activity level Changes in how fat and blood sugar are metabolized by your body Retention of salt and water in tissues leads to weight gain Studies have shown after starting thyroid replacement medication with T4, weight loss can occur

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The SURMOUNT-4 trial with tirzepatide showed that participants who continued the medication lost an additional 5.5% of their body weight, while those who switched to a placebo regained 14%

For the second primary endpoint of percentage change in body weight from baseline to 52 weeks, semaglutide had a consistent beneficial effect across diuretic use categories