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Another advantage of disulfides is that they can be attached directly to the cysteine of the antibody, resulting in a cleavable linker with fewer atoms added to the drug-linker complex

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The characteristic inflammation in asthma is primarily driven by immune responses, particularly those that involve Th cells and various cytokines

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64.1200, et seq

In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation