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Interestingly, in mice, genetic elimination of the glucagon receptor ( Gcgr / ) leads to a ~3 to 30-fold increase in physiological circulating GLP-1 and GLP-2 levels 19,20,21 , as well as increased small and large intestinal length 15 , indicating that increasing endogenous levels of GLP-1 and GLP-2 can also lead to an expansion of the gut surface area

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