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doi: 10.1056/nejmoa2200433 17 KellyAS

Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

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The schedule of the visible effects of this medication differs in various modes of administration, dosage, or individual physiology: Oral Supplements: It might take 8 to 12 weeks to see the results IV Treatments: Skin color-8-10 visits(2-3 weeks The outcomes could still be getting better as the individual goes on treatment and with proper care

3 Results Clinical and auxological parameters were similar between all groups of patients and presented in Table 1