Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
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Transcriptomic studies have characterized the compound as influencing the expression of a large number of genes, published analyses have reported effects on the expression of more than four thousand human genes, across the directional categories studied, with notable enrichment in pathways related to extracellular matrix remodeling, cellular proliferation, antioxidant response, and copper homeostasis
Substrate recognition by FBXW7 is mediated through its WD40 domain, which specifically binds to phosphorylated sequences known as Cdc4 phosphodegrons (CPDs) present in target proteins [7, 20]
1-3 Because not everyone with symptoms possibly attributable to IBS seeks treatment, it is estimated that about 40% of individuals who would meet diagnostic criteria for IBS do not have a formal diagnosis
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