A reduced appetite is commonly noticed within the first week, which is one of the earliest signs that the medication is beginning to work
That same study noted that taking a GLP-1 was associated with a higher rate of gastrointestinal side effects, pancreatitis, and pancreatic cancers, though other studies have not confirmed this
J Clin Invest 124(6):24562463
No meaningful systemic effects at normal concentrations
Troyb, E., Orinstein, A., Tyson, K., Helt, M., Eigsti, I.M., Stevens, M., and Fein, D., Autism: The International Journal of Research and Practice , 2014, vol
Spiller RC, Trotman IF, Higgins BE, Ghatei MA, Grimble GK, Lee YC et al