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This is suggestive of a prolonged formation of catechin via gut microbial degradation of procyanidins in the colon (Figure 3)

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2 In approximately 26%39% of the CLBP cases, degeneration of the intervertebral disc (IVD) without herniation, also referred to as chronic discogenic low back pain (CDLBP), has been established to be the underlying cause

There are, however, many questions to be answered regarding the mechanisms by which these UPS components contribute to AD progression and facilitate or impede recovery of function after SCI