2361-C PREVALENCE OF INTRANUCLEAR LIPID DROPLETS IN NONALCOHOLIC FATTY LIVER DISEASE Norihiro Imai 1 , Yuki Ohsaki 2 , Jinglei Cheng 1 , Jingjing Zhang 1 , Fumitaka Mizuno 1 , Taku Tanaka 1 , Shinya Yokoyama 1 , Kenta Yamamoto 1 , Takanori Ito 1 , Yoji Ishizu 1 , Takashi Honda 1 , Masatoshi Ishigami 1 , Hiroaki Wake 1 and Hiroki Kawashima 1 , (1)Nagoya University Graduate School of Medicine, (2)Sapporo Medical University Background: Lipid droplets (LDs) are organelles found in not only adipocytes but also various cells throughout the body, and they store excess energy while also fulfilling a multitude of physiological functions
Hereditary hemochromatosis restores the virulence of plague vaccine strains
& Groner, Y
Conclusion: These data provide the first direct experimental evidence that voluntary running wheel exercise, independent of weight loss, prevents the aggravation of diet-induced hepatic steatosis and fibrosis in a clinically relevant mouse model of MAFLD
Intrinsic DILI is predictable and observed in preclinical studies 57, 58
PMID 727443