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While these can reduce inflammation, they often bring difficult side effects: Weight gain, bloating, and bone loss Increased infection risk Fatigue and mood changes High long-term costs Because these drugs suppress the immune system instead of balancing it, flare-ups frequently return once treatment stops

Muscle Loss Approximately 2540% of total weight lost on GLP-1 RAs comes from lean body mass, with muscle comprising roughly half of this loss

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doi: 10.1038/s42255-018-0031-6 365 Vila-CastelarC.AkinciM.PalpatzisE.Aguilar-DominguezP.OpertoG.KollmorgenG.et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Suravajjala S., Cohenford M., Frost L.R., Pampati P.K., Dain J.A