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Diabetes 55 (Suppl

JAMA 325(22):22622272

View image online ( illustration showing action of a GLP-1 receptor agonist For the first time, a pharmacotherapy for overweight and obesity has been shown to reduce cardiovascular events in patients with established cardiovascular disease (CVD) in the absence of type 2 diabetes

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In a model of non-proteinuric diabetic kidney disease of high-fat-diet-fed ApoE-knockout mice, ATP production changes from lipolysis- to ketolysis-dependent, due to hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1)

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